Open AccessCost-effectiveness of Short-Course Radiation Therapy vs Long-Course Chemoradiation for Locally Advanced Rectal Cancer
Author(s) -
Ann C. Raldow,
Aileen B. Chen,
Marcia M. Russell,
Percy P. Lee,
Theodore S. Hong,
David P. Ryan,
James C. Cusack,
Jennifer Y. Wo
Publication year - 2019
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2019.2249
Subject(s) - medicine , chemoradiotherapy , radiation therapy , colorectal cancer , cost effectiveness , abdominoperineal resection , short course , cost effectiveness analysis , oncology , cancer , surgery , pediatrics , risk analysis (engineering)
Key Points Question What is the cost-effectiveness of short-course radiotherapy vs long-course chemoradiotherapy for patients with locally advanced rectal cancer? Findings In this economic evaluation, short-course radiotherapy was the cost-effective strategy, with an incremental cost-effectiveness ratio of $133 495 per quality-adjusted life-year. However, for the subset of patients with distal tumors, long-course chemoradiotherapy was the cost-effective approach, with an incremental cost-effectiveness ratio of $61 123 per quality-adjusted life-year. Meaning Patients with locally advanced rectal cancer should be treated with preoperative short-course radiation therapy unless they require tumor downstaging prior to resection, in which case long-course chemoradiotherapy is cost-effective.
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