Associations of Prenatal and Childhood Antibiotic Exposure With Obesity at Age 4 Years | Zendy

Karen S. W. Leong | Zendy; Jessica McLay | Zendy; José G. B. Derraik | Zendy; Sheree Gibb | Zendy; Nichola Shackleton | Zendy; Rachael W. Taylor | Zendy; Marewa Glover | Zendy; Rick Audas | Zendy; Barry Taylor | Zendy; Barry Milne | Zendy; Wayne S. Cutfield | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Associations of Prenatal and Childhood Antibiotic Exposure With Obesity at Age 4 Years

Author(s) -

Karen S. W. Leong,

Jessica McLay,

José G. B. Derraik,

Sheree Gibb,

Nichola Shackleton,

Rachael W. Taylor,

Marewa Glover,

Rick Audas,

Barry Taylor,

Barry Milne,

Wayne S. Cutfield

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2019.19681

Subject(s) - medicine , pediatrics , pregnancy , childhood obesity , obesity , anthropometry , population , body mass index , birth weight , odds ratio , early childhood , demography , overweight , environmental health , genetics , sociology , biology , psychology , developmental psychology

Key Points Question Is antibiotic exposure during pregnancy and/or during early childhood associated with the development of childhood obesity? Findings This cross-sectional national study of 284 211 participants (132 852 mothers and 151 359 children) in New Zealand found that both prenatal and early childhood exposures to antibiotics were independently associated with obesity at age 4 years in a dose-dependent manner. However, fixed-effects analyses of siblings and twins with discordant outcomes showed no associations between antibiotic exposure and obesity. Meaning Although judicious use of antibiotics is necessary, antibiotics are unlikely to be a major contributor to childhood obesity.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research