Social Brain Functional Maturation in Newborn Infants With and Without a Family History of Autism Spectrum Disorder | Zendy

Judit Ciarrusta | Zendy; Jonathan O’Muircheartaigh | Zendy; Ralica Dimitrova | Zendy; Dafnis Batallé | Zendy; Lucilio CorderoGrande | Zendy; Anthony N. Price | Zendy; Emer Hughes | Zendy; Johannes K. Steinweg | Zendy; Johanna Kangas | Zendy; Emily Perry | Zendy; Ayesha Javed | Zendy; Vladimira Stoencheva | Zendy; Ranjit Akolekar | Zendy; Suresh Victor | Zendy; Joseph V. Hajnal | Zendy; Declan Murphy | Zendy; A. David Edwards | Zendy; Tomoki Arichi | Zendy; Gráinne McAlonan | Zendy

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Social Brain Functional Maturation in Newborn Infants With and Without a Family History of Autism Spectrum Disorder

Author(s) -

Judit Ciarrusta,

Jonathan O’Muircheartaigh,

Ralica Dimitrova,

Dafnis Batallé,

Lucilio CorderoGrande,

Anthony N. Price,

Emer Hughes,

Johannes K. Steinweg,

Johanna Kangas,

Emily Perry,

Ayesha Javed,

Vladimira Stoencheva,

Ranjit Akolekar,

Suresh Victor,

Joseph V. Hajnal,

Declan Murphy,

A. David Edwards,

Tomoki Arichi,

Gráinne McAlonan

Publication year - 2019

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2019.1868

Subject(s) - autism spectrum disorder , autism , family history , functional magnetic resonance imaging , vulnerability (computing) , brain activity and meditation , cohort , psychology , neurodevelopmental disorder , developmental psychology , pediatrics , medicine , neuroscience , electroencephalography , computer security , computer science

Key Points Question Are changes in the maturation of the social brain in infants associated with vulnerability to neurodevelopmental conditions such as autism spectrum disorder? Findings In this cohort study of 36 neonates with and without a family history of autism spectrum disorder, newborns with a family history of autism spectrum disorder had significantly higher neural activity in the right fusiform and left parietal cortex. In addition, the pattern of age-related changes in spontaneous activity in the cingulate and insula was disrupted in infants with a family history of autism spectrum disorder. Meaning Atypical development of functional activity patterns in key regions responsible for social processing may be a vulnerability mechanism for autism.

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