Open AccessIncidence and Prognosis of Acute Kidney Diseases and Disorders Using an Integrated Approach to Laboratory Measurements in a Universal Health Care System
Author(s) -
Matthew T. James,
Andrew S. Levey,
Marcello Tonelli,
Zhi Tan,
Rebecca Barry,
Neesh Pannu,
Pietro Ravani,
Scott Klarenbach,
Braden Manns,
Brenda R. Hemmelgarn
Publication year - 2019
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2019.1795
Subject(s) - medicine , kidney disease , acute kidney injury , renal function , guideline , albuminuria , incidence (geometry) , intensive care medicine , cohort , renal replacement therapy , retrospective cohort study , creatinine , cohort study , nephrology , pathology , physics , optics
Key Points Question Do the acute kidney diseases and disorders (AKD) criteria from the Kidney Disease: Improving Global Outcomes guidelines identify patients who do not meet existing criteria for chronic kidney disease (CKD) or acute kidney injury (AKI), and what is the prognosis of these patients? Findings In this cohort study of 1.1 million Canadian residents, AKD criteria identified many patients who did not meet existing criteria for CKD or AKI, and patients with AKD without AKI had overall modestly increased risks of incident and progressive CKD, end-stage kidney disease, and death. Meaning The incorporation of AKD into clinical and research initiatives for kidney disease would increase recognition of patients at risk of adverse outcomes who are not identified by current AKI and CKD criteria; however, the clinical importance of AKD remains to be determined.
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