Global Epidemiologic Characteristics of Sexually Transmitted Infections Among Individuals Using Preexposure Prophylaxis for the Prevention of HIV Infection | Zendy

Jason J. Ong | Zendy; Rachel Clare Baggaley | Zendy; Teodora Wi | Zendy; Joseph D. Tucker | Zendy; Hongyun Fu | Zendy; M. Kumi Smith | Zendy; Sabrina Rafael | Zendy; Vanessa Anglade | Zendy; Jane Falconer | Zendy; Richard OforiAsenso | Zendy; Fern TerrisPrestholt | Zendy; Ioannis Hodges-Mameletzis | Zendy; Philippe Mayaud | Zendy

Open Access

Global Epidemiologic Characteristics of Sexually Transmitted Infections Among Individuals Using Preexposure Prophylaxis for the Prevention of HIV Infection

Author(s) -

Jason J. Ong,

Rachel Clare Baggaley,

Teodora Wi,

Joseph D. Tucker,

Hongyun Fu,

M. Kumi Smith,

Sabrina Rafael,

Vanessa Anglade,

Jane Falconer,

Richard OforiAsenso,

Fern TerrisPrestholt,

Ioannis Hodges-Mameletzis,

Philippe Mayaud

Publication year - 2019

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2019.17134

Subject(s) - medicine , chlamydia , gonorrhea , incidence (geometry) , syphilis , men who have sex with men , pre exposure prophylaxis , demography , emtricitabine , human immunodeficiency virus (hiv) , immunology , viral load , antiretroviral therapy , physics , sociology , optics

Key Points Question What is the burden of sexually transmitted infections among individuals using preexposure prophylaxis (emtricitabine and tenofovir disoproxil fumarate) for the prevention of HIV infection? Findings This systematic review and meta-analysis identified 88 studies (71 published and 17 unpublished), with 26 (30%) from low- and middle-income countries. For studies reporting a composite outcome of chlamydia, gonorrhea, and early syphilis, the pooled prevalence was 23.9% at initiation of HIV preexposure prophylaxis, and the pooled incidence was 72.2 per 100 person-years during HIV preexposure prophylaxis. Meaning These estimates indicate a high burden of sexually transmitted infections among individuals initiating preexposure prophylaxis and persistent users of preexposure prophylaxis for the prevention of HIV infection, highlighting the opportunities for active integration of services for sexually transmitted infections and HIV preexposure prophylaxis.

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