Association Between Acute Gastroenteritis and Continuous Use of Proton Pump Inhibitors During Winter Periods of Highest Circulation of Enteric Viruses | Zendy

AnaMaria Vilcu | Zendy; Laure Sabatte | Zendy; Thierry Blanchon | Zendy; Cécile Souty | Zendy; Milka Maravic | Zendy; Magali Lemaître | Zendy; O. Steichen | Zendy; Thomas Hanslik | Zendy

Open Access

Association Between Acute Gastroenteritis and Continuous Use of Proton Pump Inhibitors During Winter Periods of Highest Circulation of Enteric Viruses

Author(s) -

AnaMaria Vilcu,

Laure Sabatte,

Thierry Blanchon,

Cécile Souty,

Milka Maravic,

Magali Lemaître,

O. Steichen,

Thomas Hanslik

Publication year - 2019

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2019.16205

Subject(s) - medicine , interquartile range , pharmacy , pediatrics , proton pump inhibitor , cohort study , epidemiology , cohort , family medicine

Key Points Question Is continuous use of proton pump inhibitors (PPIs) associated with an increased risk of acute gastroenteritis during periods of highest circulation of enteric viruses? Findings In this matched cohort study comparing 233 596 patients receiving continuous PPI therapy with 626 887 patients not receiving PPI therapy, the adjusted relative risk of occurrence of acute gastroenteritis during periods of highest circulation of enteric viruses was 1.81 times higher in patients receiving continuous PPI therapy than in those not receiving PPI therapy. Meaning Continuous PPI use may be associated with an increased risk of enteric viral infections.

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