Open AccessEffect of Mailed Human Papillomavirus Test Kits vs Usual Care Reminders on Cervical Cancer Screening Uptake, Precancer Detection, and Treatment
Author(s) -
Rachel L. Winer,
John Lin,
Jasmin A. Tiro,
Diana L. Miglioretti,
Tara Beatty,
Hongyuan Gao,
Kilian Kimbel,
Chris Thayer,
Diana S. M. Buist
Publication year - 2019
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2019.14729
Subject(s) - medicine , randomized controlled trial , cervical cancer , cervical screening , cervical intraepithelial neoplasia , family medicine , gynecology , hysterectomy , cancer , obstetrics , surgery
Key Points Question Do mailed human papillomavirus self-sampling kits increase detection and treatment of cervical precancers and screening uptake vs usual care (reminders for in-clinic screening)? Findings This randomized clinical trial included 19 851 women; 26% were screened after receiving a human papillomavirus kit vs 17% with usual care, a significant difference. There was no statistically significant difference in the number of cases of precancers detected or treated. Meaning This study indicates that mailing human papillomavirus kits to underscreened women can increase cervical cancer screening, and implementation efforts should strategize how to further increase kit uptake and follow-up of positive results to maximize detection and treatment of precancers in women at high risk.
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