Open AccessAssociation of Chorioamnionitis With Bronchopulmonary Dysplasia Among Preterm Infants
Author(s) -
Eduardo Villamor-Martínez,
María Álvarez-Fuente,
Amro M. T. Ghazi,
Pieter Degraeuwe,
Luc J. I. Zimmermann,
Boris W. Kramer,
Eduardo Villamor
Publication year - 2019
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2019.14611
Subject(s) - bronchopulmonary dysplasia , medicine , chorioamnionitis , confounding , gestational age , odds ratio , pediatrics , respiratory distress , meta analysis , premature birth , gestation , necrotizing enterocolitis , obstetrics , pregnancy , surgery , genetics , biology
Key Points Question Is chorioamnionitis a risk factor for developing bronchopulmonary dysplasia in preterm infants? Findings This systematic review, meta-analysis, and metaregression found that chorioamnionitis was associated with an increased risk of bronchopulmonary dysplasia in preterm infants but also found significant differences in baseline characteristics between infants with and infants without chorioamnionitis. A multivariate metaregression model combining the difference in gestational age and the odds of respiratory distress syndrome was associated with 64% of the variance in the association between chorioamnionitis and bronchopulmonary dysplasia. Meaning Exposure to chorioamnionitis is associated with a higher risk of developing bronchopulmonary dysplasia in preterm infants, but this association may be modulated by gestational age and risk of respiratory distress syndrome.
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