Open AccessAssociation of Apolipoprotein E ɛ4, Educational Level, and Sex With Tau Deposition and Tau-Mediated Metabolic Dysfunction in Older Adults
Author(s) -
Vijay K. Ramanan,
Anna Castillo,
David S. Knopman,
Jonathan GraffRadford,
Val J. Lowe,
Ronald C. Petersen,
Clifford R. Jack,
Michelle M. Mielke,
Prashanthi Vemuri
Publication year - 2019
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2019.13909
Subject(s) - association (psychology) , deposition (geology) , apolipoprotein b , apolipoprotein e , medicine , psychology , gerontology , endocrinology , biology , disease , psychotherapist , cholesterol , paleontology , sediment
Key Points Question Are the apolipoprotein E ɛ4 allele, educational levels, and sex associated with tau deposition and tau-mediated metabolic dysfunction in older adults? Findings In a population-based cohort study, regional tau deposition was most significantly associated with global amyloid burden without any main associations of apolipoprotein E ɛ4, education, or sex. Via interaction models, women displayed a higher degree of tau-mediated metabolic dysfunction in the entorhinal cortex compared with men. Meaning These findings suggest that in older adults, tau deposition is most significantly associated with amyloidosis, but other factors, including sex, may be associated with differential resilience to tau pathology.
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