A Comparison of Pneumococcal Nasopharyngeal Carriage in Very Young Fijian Infants Born by Vaginal or Cesarean Delivery | Zendy

Eleanor Neal | Zendy; Cattram Nguyen | Zendy; F. Tupou Ratu | Zendy; Silivia Matanitobua | Zendy; Eileen M. Dunne | Zendy; Rita Reyburn | Zendy; Mike Kama | Zendy; Rachel Devi | Zendy; Kylie Jenkins | Zendy; Lisi Tikoduadua | Zendy; Joseph Kado | Zendy; Eric Rafai | Zendy; Catherine Satzke | Zendy; Kim Mulholland | Zendy; Fiona M. Russell | Zendy

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A Comparison of Pneumococcal Nasopharyngeal Carriage in Very Young Fijian Infants Born by Vaginal or Cesarean Delivery

Author(s) -

Eleanor Neal,

Cattram Nguyen,

F. Tupou Ratu,

Silivia Matanitobua,

Eileen M. Dunne,

Rita Reyburn,

Mike Kama,

Rachel Devi,

Kylie Jenkins,

Lisi Tikoduadua,

Joseph Kado,

Eric Rafai,

Catherine Satzke,

Kim Mulholland,

Fiona M. Russell

Publication year - 2019

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2019.13650

Subject(s) - carriage , medicine , serotype , pediatrics , vaginal delivery , streptococcus pneumoniae , pneumococcal infections , pneumococcal conjugate vaccine , transmission (telecommunications) , demographics , pregnancy , obstetrics , immunology , demography , biology , microbiology and biotechnology , electrical engineering , pathology , genetics , engineering , antibiotics , sociology

Key Points Question Is pneumococcal nasopharyngeal carriage associated with mode of delivery in Fijian infants aged 5 to 8 weeks? Findings In this cross-sectional study, pneumococcal nasopharyngeal carriage prevalence, density, and serotype range were higher in infants delivered vaginally vs cesarean delivery. After adjustment, vaginal delivery was positively associated with pneumococcal nasopharyngeal carriage. Meaning These findings may be owing to differential exposure to the vaginal microbiota during delivery and the association of intrapartum antibiotics with the infant microbiome, and raises the hypothesis of vertical transmission.

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