Association Between Angiotensin-Converting Enzyme Inhibitors, Angiotensin Receptor Blockers, and Suicide

Key Points Question Are angiotensin receptor blockers associated with a higher risk of suicide than angiotensin-converting enzyme inhibitors? Findings In this case-control study of 964 older adults who died by suicide and 3856 matched control participants, compared with angiotensin-converting enzyme inhibitors, exposure to angiotensin receptor blockers was associated with a higher risk of suicide. Findings were consistent in a sensitivity analysis that excluded individuals with a history of self-harm. Meaning Angiotensin receptor blockers may be associated with a higher risk of suicide than angiotensin-converting enzyme inhibitors.