Association of Estimated Pulse Wave Velocity With Survival | Zendy

Charalambos Vlachopoulos | Zendy; Dimitrios TerentesPrintzios | Zendy; Stéphane Laurent | Zendy; Peter M. Nilsson | Zendy; Athanase D. Protogerou | Zendy; K. Aznaouridis | Zendy; Panagiotis Xaplanteris | Zendy; Iosif Koutagiar | Zendy; Hirofumi Tomiyama | Zendy; Akira Yamashina | Zendy; Petros P. Sfikakis | Zendy; Dimitrios Tousoulis | Zendy

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Association of Estimated Pulse Wave Velocity With Survival

Author(s) -

Charalambos Vlachopoulos,

Dimitrios TerentesPrintzios,

Stéphane Laurent,

Peter M. Nilsson,

Athanase D. Protogerou,

K. Aznaouridis,

Panagiotis Xaplanteris,

Iosif Koutagiar,

Hirofumi Tomiyama,

Akira Yamashina,

Petros P. Sfikakis,

Dimitrios Tousoulis

Publication year - 2019

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2019.12831

Subject(s) - medicine , pulse wave velocity , blood pressure , sprint , hazard ratio , cardiology , myocardial infarction , arterial stiffness , pulse pressure , proportional hazards model , stroke (engine) , population , framingham risk score , post hoc analysis , confidence interval , physical therapy , mechanical engineering , environmental health , disease , engineering

Key Points Question Do estimated markers of aortic stiffness, such as estimated pulse wave velocity and their change with time, predict cardiovascular events in individuals with hypertension? Findings The results of this post hoc analysis of the randomized Systolic Blood Pressure Intervention Trial (SPRINT) support an incremental predictive role of estimated pulse wave velocity with outcomes beyond Framingham Risk Score. Individuals whose estimated pulse wave velocity responded to 1 year of antihypertensive treatment demonstrated a 42% lower risk of death compared with nonresponders independent of systolic blood pressure reduction in the standard treatment group of the Systolic Blood Pressure Intervention Trial. Meaning Aortic stiffness could be used in individuals with hypertension to assess risk; it could be used also as a therapeutic target to assist patient management and improve prognosis.

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