Association of BCG Vaccination in Childhood With Subsequent Cancer Diagnoses | Zendy

Nicholas Usher | Zendy; Suyoung Chang | Zendy; Robin Howard | Zendy; Adriana Martinez | Zendy; Lee H. Harrison | Zendy; Mathuram Santosham | Zendy; Naomi Aronson | Zendy

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Association of BCG Vaccination in Childhood With Subsequent Cancer Diagnoses

Author(s) -

Nicholas Usher,

Suyoung Chang,

Robin Howard,

Adriana Martinez,

Lee H. Harrison,

Mathuram Santosham,

Naomi Aronson

Publication year - 2019

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2019.12014

Subject(s) - medicine , vaccination , tuberculosis , bcg vaccine , interquartile range , placebo , randomized controlled trial , immunology , pediatrics , alternative medicine , pathology

Key Points Question What is the association of BCG vaccination during childhood with subsequent cancer development? Findings In this 60-year follow-up of a clinical trial of the BCG vaccine that included 2963 participants vaccinated at a median age of 8 years, those who received the BCG vaccine had a subsequent lung cancer rate of 18.2 cases per 100 000 person-years. Participants who received the placebo had a lung cancer rate of 45.4 cases per 100 000 person-years. Meaning The findings suggest that receiving BCG vaccination during early childhood is associated with reduced risk of subsequent lung cancer development.

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