Combined Association of Body Mass Index and Alcohol Consumption With Biomarkers for Liver Injury and Incidence of Liver Disease

Key Points Question Is there a joint association of body mass index and alcohol consumption with liver disease and liver injury biomarkers? Findings In this mendelian randomization study of a population-based cohort of 91 552 European adults, compared with individuals categorized as having both a high body mass index and weekly units of alcohol consumption, those in the low category for both of these risk factors were associated with lower circulating liver injury biomarkers compared with being high for either one or both of the risk factors. However, this association was less clear when considering cases of liver disease as the outcome. Meaning Interventions to reduce both body mass index and alcohol consumption may result in the greatest reduction in circulating liver injury biomarkers, but these results do not appear to be able to demonstrate whether these interventions will result in a reduction in cases of liver disease.