Association of Long-term Use of Low-Dose Aspirin as Chemoprevention With Risk of Lung Cancer

Key Points Question Is long-term use of low-dose aspirin associated with reduced risk of lung cancer, and if so, which populations may derive the greatest benefit? Findings This cohort study using data from 12 969 400 participants in the Korean National Health Information Database found that the use of low-dose aspirin for more than 5 years was associated with a modest risk reduction of incident lung cancer, with the strongest association observed among elderly participants and among people without diabetes. Meaning Intake of low-dose aspirin for more than 5 years may reduce the risk of incident lung cancer, particularly among the elderly and among people without diabetes.