Association of Infants Exposed to Prenatal Zika Virus Infection With Their Clinical, Neurologic, and Developmental Status Evaluated via the General Movement Assessment Tool | Zendy

Christa Einspieler | Zendy; Fabiana Utsch | Zendy; Patrícia Brasil | Zendy; Carolina Yuri Panvequio Aizawa | Zendy; Colleen Peyton | Zendy; Renata Hydeé Hasue | Zendy; Fernanda Françoso Genovesi | Zendy; Luana Damasceno | Zendy; Maria Elisabeth Lopes Moreira | Zendy; Kristina Adachi | Zendy; Peter B. Marschik | Zendy; Karin NielsenSaines | Zendy

Open Access

Association of Infants Exposed to Prenatal Zika Virus Infection With Their Clinical, Neurologic, and Developmental Status Evaluated via the General Movement Assessment Tool

Author(s) -

Christa Einspieler,

Fabiana Utsch,

Patrícia Brasil,

Carolina Yuri Panvequio Aizawa,

Colleen Peyton,

Renata Hydeé Hasue,

Fernanda Françoso Genovesi,

Luana Damasceno,

Maria Elisabeth Lopes Moreira,

Kristina Adachi,

Peter B. Marschik,

Karin NielsenSaines

Publication year - 2019

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2018.7235

Subject(s) - bayley scales of infant development , medicine , zika virus , microcephaly , pediatrics , toddler , gestational age , neurotypical , cohort , rash , pregnancy , autism , psychomotor learning , cognition , psychology , autism spectrum disorder , psychiatry , immunology , developmental psychology , virus , genetics , biology

Key Points Question Is there an association between general movement assessment results and neurodevelopment in infants with vertical Zika virus exposure? Findings In this cohort study of 444 children, including 111 prenatally exposed to acute maternal illness with rash during the Zika epidemic, general movement assessment was associated with neurodevelopment at age 12 months (94% negative predictive value, 78% positive predictive value, 70% sensitivity, 96% specificity, and 91% accuracy). The Motor Optimality Score was 23 in children with normal development, 12 in children with adverse outcomes, and 5 in children with microcephaly, a significant difference. Meaning General movement assessment is a helpful tool in the evaluation of neurodevelopment in Zika virus–exposed children.

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