Association Between Noninvasive Fibrosis Markers and Postoperative Mortality After Hepatectomy for Hepatocellular Carcinoma | Zendy

Felipe B. Maegawa | Zendy; Lauren Shehorn | Zendy; Hassan Aziz | Zendy; John B. Kettelle | Zendy; Tun Jie | Zendy; Taylor S. Riall | Zendy

Open Access

Association Between Noninvasive Fibrosis Markers and Postoperative Mortality After Hepatectomy for Hepatocellular Carcinoma

Author(s) -

Felipe B. Maegawa,

Lauren Shehorn,

Hassan Aziz,

John B. Kettelle,

Tun Jie,

Taylor S. Riall

Publication year - 2019

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2018.7142

Subject(s) - medicine , hepatocellular carcinoma , gastroenterology , ascites , cirrhosis , hepatectomy , liver function , cohort , perioperative , retrospective cohort study , surgery , resection

Key Points Question Are the noninvasive fibrosis markers aspartate aminotransferase–platelet ratio index and fibrosis 4 associated with perioperative mortality and overall survival after hepatectomy for hepatocellular carcinoma? Findings In this cohort study of 475 US veterans, aspartate aminotransferase–platelet ratio index and fibrosis 4 were independently associated with increased 30- and 90-day mortality and worse overall survival. They were shown to improve the estimation of postoperative mortality. Meaning This study suggests that the incorporation of aspartate aminotransferase–platelet ratio index and fibrosis 4 in the selection criteria of hepatectomy for hepatocellular carcinoma may be warranted.

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