Morbidity and Mortality Rates Following Cytoreductive Surgery Combined With Hyperthermic Intraperitoneal Chemotherapy Compared With Other High-Risk Surgical Oncology Procedures | Zendy

Jason M. Foster | Zendy; Richard Sleightholm | Zendy; Asish Patel | Zendy; Valerie Shostrom | Zendy; Bradley R. Hall | Zendy; Beth K. Neilsen | Zendy; David L. Bartlett | Zendy; Lynette M. Smith | Zendy

Open Access

Morbidity and Mortality Rates Following Cytoreductive Surgery Combined With Hyperthermic Intraperitoneal Chemotherapy Compared With Other High-Risk Surgical Oncology Procedures

Author(s) -

Jason M. Foster,

Richard Sleightholm,

Asish Patel,

Valerie Shostrom,

Bradley R. Hall,

Beth K. Neilsen,

David L. Bartlett,

Lynette M. Smith

Publication year - 2019

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2018.6847

Subject(s) - medicine , pancreaticoduodenectomy , interquartile range , perioperative , esophagectomy , hyperthermic intraperitoneal chemotherapy , surgery , retrospective cohort study , general surgery , hepatectomy , cohort , surgical oncology , complication , database , cancer , cytoreductive surgery , esophageal cancer , resection , computer science , ovarian cancer

Key Points Question What are the morbidity and mortality of cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) compared with other major oncologic surgical procedures? Findings In this cohort study of 1822 patients who received CRS/HIPEC compared with patients who received other high-risk surgical oncology procedures, overall 30-day mortality was lower in CRS/HIPEC (1.1%) compared with pancreaticoduodenectomy (2.5%), right lobe hepatectomy (2.9%), esophagectomy (3.0%), and trisegmental hepatectomy (3.9%). Meaning Comparative analysis revealed CRS/HIPEC to be safe across the spectrum of National Surgical Quality Improvement Project safety metrics when compared with oncologic procedures with similar inherent risk.

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