Association of a Combined Measure of Adherence and Treatment Intensity With Cardiovascular Outcomes in Patients With Atherosclerosis or Other Cardiovascular Risk Factors Treated With Statins and/or Ezetimibe | Zendy

Kamlesh Khunti | Zendy; Mark D. Danese | Zendy; Lucie Kutikova | Zendy; David Catterick | Zendy; Francisco Sorio-Vilela | Zendy; Michelle Gleeson | Zendy; Sreenivasa Rao Kondapally Seshasai | Zendy; Jack Brownrigg | Zendy; Kausik K. Ray | Zendy

Open Access

Association of a Combined Measure of Adherence and Treatment Intensity With Cardiovascular Outcomes in Patients With Atherosclerosis or Other Cardiovascular Risk Factors Treated With Statins and/or Ezetimibe

Author(s) -

Kamlesh Khunti,

Mark D. Danese,

Lucie Kutikova,

David Catterick,

Francisco Sorio-Vilela,

Michelle Gleeson,

Sreenivasa Rao Kondapally Seshasai,

Jack Brownrigg,

Kausik K. Ray

Publication year - 2018

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2018.5554

Subject(s) - medicine , ezetimibe , hazard ratio , myocardial infarction , diabetes mellitus , type 2 diabetes , statin , kidney disease , stroke (engine) , medical prescription , retrospective cohort study , angina , heart failure , cardiology , confidence interval , endocrinology , pharmacology , mechanical engineering , engineering

Results of this study demonstrate that the lowest cardiovascular risk was observed among adherent patients receiving high-intensity therapy, and the highest cardiovascular risk was observed among nonadherent patients receiving low-intensity therapy. Strategies that improve adherence and greater use of intensive therapies could substantially improve cardiovascular risk.

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