Association of Primary Care Consultation Patterns With Early Signs and Symptoms of Psychosis

Key Points Question Are primary care consultation patterns for prespecified nonspecific symptoms associated with a psychotic diagnosis? Findings In this case-control study of 11 690 adults with psychosis and 81 793 matched controls without psychosis, 12 clinical high-risk symptoms, analyzed by sex and age group, were associated with a psychosis diagnosis, with suicidal behavior having the highest associated risk for psychosis. Pairs of symptoms were associated with an increase in the positive predictive value for a diagnosis of psychosis. Meaning These findings are the first stage in the development and validation of a prognostic model of psychosis for primary care by providing candidate predictors and counter the generally held belief that individuals with emerging psychosis do not seek help from a medical professional.