Evaluation of Differences in Temporal Synchrony Between Brain Regions in Individuals With Autism and Typical Development | Zendy

Jace B. King | Zendy; Molly B. D. Prigge | Zendy; Carolyn K. King | Zendy; Jubel Morgan | Zendy; Douglas Dean | Zendy; Abigail Freeman | Zendy; Joaquin Alfonso M. Villaruz | Zendy; K. Kane | Zendy; Erin D. Bigler | Zendy; Andrew L. Alexander | Zendy; Nicholas Lange | Zendy; Brandon A. Zielinski | Zendy; Janet E. Lainhart | Zendy; Jeffrey S. Anderson | Zendy

Open Access

Evaluation of Differences in Temporal Synchrony Between Brain Regions in Individuals With Autism and Typical Development

Author(s) -

Jace B. King,

Molly B. D. Prigge,

Carolyn K. King,

Jubel Morgan,

Douglas Dean,

Abigail Freeman,

Joaquin Alfonso M. Villaruz,

K. Kane,

Erin D. Bigler,

Andrew L. Alexander,

Nicholas Lange,

Brandon A. Zielinski,

Janet E. Lainhart,

Jeffrey S. Anderson

Publication year - 2018

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2018.4777

Subject(s) - autism , psychology , functional magnetic resonance imaging , replication (statistics) , autism spectrum disorder , sample size determination , neuroimaging , audiology , developmental psychology , neuroscience , medicine , statistics , mathematics , virology

Key Points Question Do individuals with autism show atypical duration of brain functional connections? Findings In this cohort study of 52 individuals with autism and 38 typically developing participants and a replication study of 1402 participants in a brain imaging database, increased durations of functional connections in autism were found in both distributed networks and individual brain regions, which were associated with metrics of disease severity. Meaning Persistence of brain connectivity in autism may limit the ability to rapidly shift from one brain state to another and contribute to the pathophysiology of autism.

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