Development and Validation of a Nomogram for Assessing Survival in Patients With Metastatic Lung Cancer Referred for Radiotherapy for Bone Metastases | Zendy

Wing-Keen Yap | Zendy; MingChieh Shih | Zendy; Chin Kuo | Zendy; PingChing Pai | Zendy; Wen-Chi Chou | Zendy; KaiPing Chang | Zendy; MuHung Tsai | Zendy; NganMing Tsang | Zendy

Open Access

Development and Validation of a Nomogram for Assessing Survival in Patients With Metastatic Lung Cancer Referred for Radiotherapy for Bone Metastases

Author(s) -

Wing-Keen Yap,

MingChieh Shih,

Chin Kuo,

PingChing Pai,

Wen-Chi Chou,

KaiPing Chang,

MuHung Tsai,

NganMing Tsang

Publication year - 2018

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2018.3242

Subject(s) - nomogram , medicine , lung cancer , radiation therapy , proportional hazards model , akaike information criterion , cancer , surgery , oncology , radiology , statistics , mathematics

Key Points Question What are the optimal factors to use for constructing a nomogram to assess the probability of survival in patients with bone metastases arising from lung cancer? Findings This prognostic study of 477 patients with metastatic lung cancer found that age, histological type, smoking status, epidermal growth factor receptor mutation status, body mass index, and neutrophil to lymphocyte ratio were ideal parameters to construct a nomogram for potentially indicating 3-, 6-, and 12-month survival. This nomogram was successfully validated in a separate cohort of 235 patients at another institution. Meaning The study’s nomogram can guide radiation oncologists in making treatment decisions and determining the proper timing for end-of-life discussions and/or hospice referrals.

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