Assessment of Outcomes of Treatment With Oral Anticoagulants in Patients With Atrial Fibrillation and Multiple Chronic Conditions | Zendy

Amgad Mentias | Zendy; Ghanshyam Shantha | Zendy; Pulkit Chaudhury | Zendy; Mary VaughanSarrazin | Zendy

Open Access

Assessment of Outcomes of Treatment With Oral Anticoagulants in Patients With Atrial Fibrillation and Multiple Chronic Conditions

Author(s) -

Amgad Mentias,

Ghanshyam Shantha,

Pulkit Chaudhury,

Mary VaughanSarrazin

Publication year - 2018

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2018.2870

Subject(s) - atrial fibrillation , medicine , cardiology , intensive care medicine

Key Points Question What are the comparative efficacy and safety of dabigatran and rivaroxaban compared with warfarin in patients with multiple chronic conditions? Findings In this comparative effectiveness analysis, stroke rates were similar between the 3 drugs. However, bleeding rates were significantly higher with rivaroxaban compared with the other 2 drugs, while mortality rates were lower with dabigatran and rivaroxaban compared with warfarin. Meaning Rivaroxaban and dabigatran are effective in elderly patients with multiple chronic conditions, but dabigatran appears to be associated with lower bleeding rates.

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