Association Between Family History and Early-Onset Atrial Fibrillation Across Racial and Ethnic Groups | Zendy

Zain Alzahrani | Zendy; Aylin Ornelas-Loredo | Zendy; Sara D. Darbar | Zendy; Abdullah Farooqui | Zendy; Denise Mol | Zendy; Brandon Chalazan | Zendy; N. Elizabeth Villagrana | Zendy; Mark McCauley | Zendy; Sorin Lazar | Zendy; Erik Wißner | Zendy; Adarsh Bhan | Zendy; Sreenivas Konda | Zendy; Dawood Darbar | Zendy

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Association Between Family History and Early-Onset Atrial Fibrillation Across Racial and Ethnic Groups

Author(s) -

Zain Alzahrani,

Aylin Ornelas-Loredo,

Sara D. Darbar,

Abdullah Farooqui,

Denise Mol,

Brandon Chalazan,

N. Elizabeth Villagrana,

Mark McCauley,

Sorin Lazar,

Erik Wißner,

Adarsh Bhan,

Sreenivas Konda,

Dawood Darbar

Publication year - 2018

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2018.2497

Subject(s) - medicine , proband , family history , odds ratio , atrial fibrillation , cohort , ethnic group , demography , pediatrics , genetics , sociology , gene , anthropology , mutation , biology

Key Points Question What is the association of family history with the pathogenesis of early-onset atrial fibrillation in patients of African, European, and Hispanic descent? Findings In this cohort study of 664 patients, probands with early-onset atrial fibrillation were significantly more likely to have a family history of arrhythmia in first-degree relatives than patients with non–early-onset atrial fibrillation. Compared with European American probands, African American and Hispanic/Latino probands with early-onset atrial fibrillation were more likely to have a first-degree relative with arrhythmia. Meaning These findings support genetic predisposition to early-onset atrial fibrillation across individuals of European, African, and Hispanic/Latino descent and have important implications for identifying family members at risk for atrial fibrillation and sequencing candidate genes.

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