Cardiovascular Disease Among Women Who Gave Birth to an Infant With a Major Congenital Anomaly | Zendy

Eyal Cohen | Zendy; Erzsébet HorváthPuhó | Zendy; Joel G. Ray | Zendy; Lars Pedersen | Zendy; Véra Ehrenstein | Zendy; Nancy E. Adler | Zendy; Simone N. Vigod | Zendy; Arnold Milstein | Zendy; Henrik Toft Sørensen | Zendy

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Cardiovascular Disease Among Women Who Gave Birth to an Infant With a Major Congenital Anomaly

Author(s) -

Eyal Cohen,

Erzsébet HorváthPuhó,

Joel G. Ray,

Lars Pedersen,

Véra Ehrenstein,

Nancy E. Adler,

Simone N. Vigod,

Arnold Milstein,

Henrik Toft Sørensen

Publication year - 2018

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2018.2320

Subject(s) - medicine , interquartile range , pediatrics , hazard ratio , cohort , population , unstable angina , cohort study , myocardial infarction , cardiology , confidence interval , environmental health

Key Points Question Do mothers who give birth to an infant with a major congenital anomaly have increased cardiovascular risk? Findings In this cohort study of 471 344 Danish women, mothers of infants born with a major congenital anomaly had a 15% increased risk of acute myocardial infarction, coronary revascularization, or stroke compared with women without an affected infant. This elevated risk rose to 37% among women who gave birth to more severely affected infants with multiorgan congenital anomalies. Meaning Having a child with a major congenital anomaly was associated with a small but significantly increased cardiovascular risk in the mother.

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