Association of Continuation of Statin Therapy Initiated Before Transition to Chronic Dialysis Therapy With Mortality After Dialysis Initiation | Zendy

Elani Streja | Zendy; Elvira O. Gosmanova | Zendy; Miklos Z. Molnar | Zendy; Melissa Soohoo | Zendy; Hamid Moradi | Zendy; Praveen K. Potukuchi | Zendy; Kamyar KalantarZadeh | Zendy; Csaba P. Kövesdy | Zendy

Open Access

Association of Continuation of Statin Therapy Initiated Before Transition to Chronic Dialysis Therapy With Mortality After Dialysis Initiation

Author(s) -

Elani Streja,

Elvira O. Gosmanova,

Miklos Z. Molnar,

Melissa Soohoo,

Hamid Moradi,

Praveen K. Potukuchi,

Kamyar KalantarZadeh,

Csaba P. Kövesdy

Publication year - 2018

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2018.2311

Subject(s) - medicine , dialysis , kidney disease , statin , cohort , retrospective cohort study , proportional hazards model , renal replacement therapy , cohort study

Key Points Question Is the use of statins initiated during late-stage chronic kidney disease and continued after transition to dialysis associated with an improvement in subsequent survival? Findings In this cohort study of 14 298 US veterans transitioning to dialysis, the continuation of statin therapy was associated with a 28% and 18% lower risk of 12-month all-cause mortality and cardiovascular mortality, respectively, compared with the discontinuation of statin therapy. Meaning The continuation of statin therapy after transition to dialysis was associated with reduced all-cause mortality and cardiovascular mortality in veterans.

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