Sex Differences in Genetic Associations With Longevity | Zendy

Yi Zeng | Zendy; Chao Nie | Zendy; Junxia Min | Zendy; Huashuai Chen | Zendy; Xiaomin Liu | Zendy; Rui Ye | Zendy; Zhihua Chen | Zendy; Chen Bai | Zendy; Enjun Xie | Zendy; Zhaoxue Yin | Zendy; Yuebin Lv | Zendy; Jiehua Lu | Zendy; Jianxin Li | Zendy; Ting Ni | Zendy; Lars Bolund | Zendy; Kenneth C. Land | Zendy; Anatoliy I. Yashin | Zendy; Angela M. O’Rand | Zendy; Liang Sun | Zendy; Ze Yang | Zendy; Wei Tao | Zendy; Anastasia Gurinovich | Zendy; Claudio Franceschi | Zendy; Jichun Xie | Zendy; Jun Gu | Zendy; Yong Hou | Zendy; Xiao Liu | Zendy; Xun Xu | Zendy; JeanMarie Robine | Zendy; Joris Deelen | Zendy; Paola Sebastiani | Zendy; P. Eline Slagboom | Zendy; Thomas T. Perls | Zendy; Elizabeth R. Hauser | Zendy; William Gottschalk | Zendy; Qihua Tan | Zendy; Kaare Christensen | Zendy; Xiaoming Shi | Zendy; Michael W. Lutz | Zendy; XiaoLi Tian | Zendy; Huanming Yang | Zendy; James W. Vaupel | Zendy

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Sex Differences in Genetic Associations With Longevity

Author(s) -

Yi Zeng,

Chao Nie,

Junxia Min,

Huashuai Chen,

Xiaomin Liu,

Rui Ye,

Zhihua Chen,

Chen Bai,

Enjun Xie,

Zhaoxue Yin,

Yuebin Lv,

Jiehua Lu,

Jianxin Li,

Ting Ni,

Lars Bolund,

Kenneth C. Land,

Anatoliy I. Yashin,

Angela M. O’Rand,

Liang Sun,

Ze Yang,

Wei Tao,

Anastasia Gurinovich,

Claudio Franceschi,

Jichun Xie,

Jun Gu,

Yong Hou,

Xiao Liu,

Xun Xu,

JeanMarie Robine,

Joris Deelen,

Paola Sebastiani,

P. Eline Slagboom,

Thomas T. Perls,

Elizabeth R. Hauser,

William Gottschalk,

Qihua Tan,

Kaare Christensen,

Xiaoming Shi,

Michael W. Lutz,

XiaoLi Tian,

Huanming Yang,

James W. Vaupel

Publication year - 2018

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2018.1670

Subject(s) - longevity , biology , demography , population , genetics , sociology

Key Points Question Are there sex differences in genetic associations with longevity? Findings In this case-control study of 2178 cases and 2299 controls who were Chinese with Han ethnicity, sex-specific genome-wide association study and sex-specific polygenic risk score analyses on longevity showed substantial and significant differences in genetic associations with longevity between men and women. Findings indicated that previously published genome-wide association studies on longevity identified some sex-independent genetic variants but missed sex-specific longevity loci and pathways. Meaning These novel findings contribute to filling the gaps in the research literature, and further investigations may substantially contribute to individualized health care and more effective and targeted health interventions for male and female elderly individuals.

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