Clinical Features and Complications ofCoxiella burnetiiInfections From the French National Reference Center for Q Fever | Zendy

Cléa Melenotte | Zendy; Camélia Protopopescu | Zendy; Matthieu Million | Zendy; Sophie Edouard | Zendy; Patrizia Carrieri | Zendy; Carole Eldin | Zendy; Emmanouil Angelakis | Zendy; F. Djossou | Zendy; Nathalie Bardin | Zendy; PierreEdouard Fournier | Zendy; JeanLouis Mège | Zendy; Didier Raoult | Zendy

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Clinical Features and Complications ofCoxiella burnetiiInfections From the French National Reference Center for Q Fever

Author(s) -

Cléa Melenotte,

Camélia Protopopescu,

Matthieu Million,

Sophie Edouard,

Patrizia Carrieri,

Carole Eldin,

Emmanouil Angelakis,

F. Djossou,

Nathalie Bardin,

PierreEdouard Fournier,

JeanLouis Mège,

Didier Raoult

Publication year - 2018

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2018.1580

Subject(s) - coxiella burnetii , q fever , medicine , serology , endocarditis , prospective cohort study , outbreak , fever of unknown origin , immunology , pediatrics , virology , antibody

Key Points Question What are the characteristics and clinical presentations of Coxiella burnetii infection using 21st-century–clarified definitions? Finding In a cohort study of 2434 patients with Q fever, the following new critical Q fever foci were identified: acute endocarditis, lymphadenitis, and bone marrow involvement in hemophagocytic syndrome. Lymphadenitis is a risk factor for lymphoma, and the elevation of IgG anticardiolipin antibody titers in acute Q fever is associated with complications. Meaning Screening for anticardiolipin antibodies may help prevent acute Q fever complications; the use of transthoracic echocardiography in acute Q fever and positron emission tomographic scanning in suspected persistent focalized infection is justified to improve the care of patients with Q fever.

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