Variability in Ejection Fraction Measured By Echocardiography, Gated Single-Photon Emission Computed Tomography, and Cardiac Magnetic Resonance in Patients With Coronary Artery Disease and Left Ventricular Dysfunction | Zendy

Patricia A. Pellikka | Zendy; Lilin She | Zendy; Thomas A. Holly | Zendy; Grace Lin | Zendy; Padmini Varadarajan | Zendy; Ramdas G. Pai | Zendy; Robert O. Bonow | Zendy; Gerald M. Pohost | Zendy; Julio A. Panza | Zendy; Daniel S. Berman | Zendy; David L. Prior | Zendy; Federico M. Asch | Zendy; Salvador BorgesNeto | Zendy; Paul Grayburn | Zendy; Hussein R. AlKhalidi | Zendy; Karol MiszalskiJamka | Zendy; Patrice DesvigneNickens | Zendy; Kerry L. Lee | Zendy; Eric J. Velazquez | Zendy; Jae K. Oh | Zendy

Open Access

Variability in Ejection Fraction Measured By Echocardiography, Gated Single-Photon Emission Computed Tomography, and Cardiac Magnetic Resonance in Patients With Coronary Artery Disease and Left Ventricular Dysfunction

Author(s) -

Patricia A. Pellikka,

Lilin She,

Thomas A. Holly,

Grace Lin,

Padmini Varadarajan,

Ramdas G. Pai,

Robert O. Bonow,

Gerald M. Pohost,

Julio A. Panza,

Daniel S. Berman,

David L. Prior,

Federico M. Asch,

Salvador BorgesNeto,

Paul Grayburn,

Hussein R. AlKhalidi,

Karol MiszalskiJamka,

Patrice DesvigneNickens,

Kerry L. Lee,

Eric J. Velazquez,

Jae K. Oh

Publication year - 2018

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2018.1456

Subject(s) - ejection fraction , medicine , cardiology , coronary artery disease , cardiac magnetic resonance imaging , magnetic resonance imaging , single photon emission computed tomography , stroke volume , heart failure , radiology , nuclear medicine

Key Points Question What is the variability in left ventricular ejection fraction (LVEF) as measured by different cardiac imaging modalities? Findings In this multicenter diagnostic study of 2032 patients with coronary artery disease and LVEF of 35% or less with imaging interpreted by core laboratories, correlation of LVEF between modalities ranged from r = 0.493 (for biplane echocardiography and cardiovascular magnetic resonance) to r = 0.660 (for cardiovascular magnetic resonance and gated single-photon emission computed tomography). There was no systematic overestimation or underestimation of LVEF for any modality. Meaning There is substantial variability in LVEF assessment between modalities, which should be considered in trial design and clinical management.

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