Rotavirus Gastroenteritis Infection Among Children Vaccinated and Unvaccinated With Rotavirus Vaccine in Southern China | Zendy

Chuanxi Fu | Zendy; Zhiqiang Dong | Zendy; Jichuan Shen | Zendy; Zhicong Yang | Zendy; Ying Liao | Zendy; Wensui Hu | Zendy; Sen Pei | Zendy; Jeffrey Shaman | Zendy

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Rotavirus Gastroenteritis Infection Among Children Vaccinated and Unvaccinated With Rotavirus Vaccine in Southern China

Author(s) -

Chuanxi Fu,

Zhiqiang Dong,

Jichuan Shen,

Zhicong Yang,

Ying Liao,

Wensui Hu,

Sen Pei,

Jeffrey Shaman

Publication year - 2018

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2018.1382

Subject(s) - medicine , rotavirus , vaccination , poisson regression , rotavirus vaccine , pediatrics , incidence (geometry) , demography , logistic regression , environmental health , diarrhea , immunology , population , physics , sociology , optics

Key Points Question What is the effect of the Lanzhou lamb rotavirus vaccination? Findings In this cross-sectional, ecological study of 33 407 patients with rotavirus gastroenteritis from 2007 to 2015 seasons in China, vaccination was associated with a 4-month increase in median age at onset and with delays in onset, peak, and cessation of incidence. The incidence rate ratio among children younger than 4 years and among children ineligible for vaccination decreased as citywide vaccination coverage increased, and the adjusted odds ratio for rotavirus gastroenteritis among unvaccinated infants decreased in areas with higher vaccination coverage. Meaning The Lanzhou lamb rotavirus vaccination can provide population health benefits in preventing rotavirus gastroenteritis, including herd effects.

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