Survival Rates for Patients With Barrett High-grade Dysplasia and Esophageal Adenocarcinoma With or Without Human Papillomavirus Infection | Zendy

Shanmugarajah Rajendra | Zendy; Wei Xuan | Zendy; Neil D. Merrett | Zendy; Preeti Sharma | Zendy; Prateek Sharma | Zendy; Darren Pavey | Zendy; Jun Yang | Zendy; Leonardo D. Santos | Zendy; Omar Sharaiha | Zendy; Girish Pande | Zendy; Peter H. Cosman | Zendy; Xiaojuan Wu | Zendy; Bin Wang | Zendy

Open Access

Survival Rates for Patients With Barrett High-grade Dysplasia and Esophageal Adenocarcinoma With or Without Human Papillomavirus Infection

Author(s) -

Shanmugarajah Rajendra,

Wei Xuan,

Neil D. Merrett,

Preeti Sharma,

Prateek Sharma,

Darren Pavey,

Jun Yang,

Leonardo D. Santos,

Omar Sharaiha,

Girish Pande,

Peter H. Cosman,

Xiaojuan Wu,

Bin Wang

Publication year - 2018

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2018.1054

Subject(s) - medicine , dysplasia , gastroenterology , adenocarcinoma , esophagus , esophageal cancer , oncology , immunohistochemistry , hpv infection , cancer , cervical cancer

Key Points Question What is the prognostic significance of esophageal tumor human papillomavirus (HPV) status? Findings In this case-control study involving 142 patients with Barrett high-grade dysplasia and esophageal adenocarcinoma, HPV positivity was associated with a significantly improved disease-free survival compared with viral negativity. Recurrence and progression were reduced in the HPV-positive cohort as were distant metastasis and death from esophageal adenocarcinoma. Meaning Barrett high-grade dysplasia and esophageal adenocarcinoma in patients who are HPV positive have a favorable prognosis compared with viral-negative esophageal tumors and may benefit from treatment de-escalation.

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