Assessment of the Diagnostic Accuracy of Biparametric Magnetic Resonance Imaging for Prostate Cancer in Biopsy-Naive Men | Zendy

Lars Boesen | Zendy; Nis Nørgaard | Zendy; Vibeke Løgager | Zendy; I. Balslev | Zendy; Rasmus Bisbjerg | Zendy; Karen-Cecilie Thestrup | Zendy; Mads Dochedahl Winther | Zendy; Henrik Jakobsen | Zendy; Henrik S. Thomsen | Zendy

Open Access

Assessment of the Diagnostic Accuracy of Biparametric Magnetic Resonance Imaging for Prostate Cancer in Biopsy-Naive Men

Author(s) -

Lars Boesen,

Nis Nørgaard,

Vibeke Løgager,

I. Balslev,

Rasmus Bisbjerg,

Karen-Cecilie Thestrup,

Mads Dochedahl Winther,

Henrik Jakobsen,

Henrik S. Thomsen

Publication year - 2018

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2018.0219

Subject(s) - prostate cancer , medicine , interquartile range , biopsy , prostate , prostate biopsy , magnetic resonance imaging , radiology , prospective cohort study , prostate specific antigen , cancer , nuclear medicine , pathology

Key Points Question What are the diagnostic accuracy and negative predictive value of novel biparametric magnetic resonance imaging (MRI) in biopsy-naive men in detecting and ruling out significant prostate cancer? Findings In this cohort study of 1020 men who underwent both biparametric targeted and standard transrectal ultrasound-guided biopsies, low-suspicion biparametric MRI had a high negative predictive value (97%) in ruling out significant prostate cancer on confirmatory biopsies. Meaning The biparametric MRI used as a triage test in this study was associated with improved prostate cancer risk stratification and may be used to exclude aggressive disease and avoid unnecessary biopsies in 30% of men with clinical suspicion of prostate cancer, although further studies are needed to fully explore this new diagnostic approach.

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