Temporal Trends and Center Variation in Early Antibiotic Use Among Premature Infants | Zendy

Dustin D. Flannery | Zendy; Rachael Ross | Zendy; Sagori Mukhopadhyay | Zendy; Alison C. Tribble | Zendy; Karen M. Puopolo | Zendy; Jeffrey S. Gerber | Zendy

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Temporal Trends and Center Variation in Early Antibiotic Use Among Premature Infants

Author(s) -

Dustin D. Flannery,

Rachael Ross,

Sagori Mukhopadhyay,

Alison C. Tribble,

Karen M. Puopolo,

Jeffrey S. Gerber

Publication year - 2018

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2018.0164

Subject(s) - medicine , neonatal intensive care unit , pediatrics , low birth weight , retrospective cohort study , antibiotics , birth weight , cohort , cohort study , pregnancy , genetics , microbiology and biotechnology , biology

Key Points Question Have empirical early antibiotic prescribing patterns for premature infants changed over time? Findings This multicenter cohort study of more than 40 000 premature infants found that most premature infants received early antibiotic administration and that rates of initiation of empirical early antibiotic therapy did not change from 2009 to 2015. Rates of prolonged antibiotic administration among very low-birth-weight infants decreased slightly, but did not change among extremely low-birth-weight infants. Meaning Despite concerns regarding the negative impact of early and prolonged empirical antibiotic use among premature newborns, neonatal clinicians across the United States continue to prescribe empirical antibiotics to the majority of very low-birth-weight infants in the first 3 days of age.

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