Publication of Randomized Clinical Trials in Pediatric Research | Zendy

Leah K. Crockett | Zendy; George N. Okoli | Zendy; Christine Neilson | Zendy; Rasheda Rabbani | Zendy; Ahmed M Abou-Setta | Zendy; Terry P. Klassen | Zendy

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Publication of Randomized Clinical Trials in Pediatric Research

Author(s) -

Leah K. Crockett,

George N. Okoli,

Christine Neilson,

Rasheda Rabbani,

Ahmed M Abou-Setta,

Terry P. Klassen

Publication year - 2018

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2018.0156

Subject(s) - randomized controlled trial , pediatric research , medicine , psychology , medical physics , pediatrics

Key Points Question What proportion of abstracts submitted to a major annual pediatric scientific meeting are subsequently published? Findings Among 129 phase 3 randomized clinical trials identified in this cohort study, 27.9% were not subsequently published, and 39.5% were never registered, with previous trial registration and sample size associated with greater likelihood of publication. Mean (SE) time to publication from study presentation was 26.48 (1.97) months, and there was evidence of publication bias among published studies. Meaning Further encouragement and follow-up are needed to ensure that the totality of evidence is made available to inform clinical decision making.

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