Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19 | Zendy

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Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19

Author(s) -

Shruti Gupta,

Wei Wang,

Salim S. Hayek,

Lili Chan,

Kusum S. Mathews,

Michal L. Melamed,

Samantha K. Brenner,

Amanda K. LeonbergYoo,

Edward J. Schenck,

Jared Radbel,

Jochen Reiser,

Anip Bansal,

Anand Srivastava,

Yan Zhou,

Diana G. Finkel,

Adam Green,

Mary C. Mallappallil,

Anthony J. Faugno,

Jingjing Zhang,

Juan Carlos Q. Velez,

Shahzad Shaefi,

Chirag R. Parikh,

David M. Charytan,

Ambarish M. Athavale,

Allon N. Friedman,

Roberta E. Redfern,

Samuel Short,

Simon Correa,

Kapil K. Pokharel,

Andrew J. Admon,

John P. Donnelly,

Hayley B. Gershengorn,

David J. Douin,

Matthew W. Semler,

Miguel A. Hernán,

David E. Leaf,

Carl P. Walther,

Samaya J. Anumudu,

Justin Arunthamakun,

Kathleen F. Kopecky,

Gregory P. Milligan,

Peter A. McCullough,

Thuy-Duyen Nguyen,

Megan L. Krajewski,

Sidharth Shankar,

Ameeka Pannu,

Juan D. Valencia,

Sushrut S. Waikar,

Zoé A. Kibbelaar,

Peter C. Hart,

Shristi Upadhyay,

Ishaan Vohra,

Oyintayo Ajiboye,

Jean-Sébastien Rachoin,

Christa Schorr,

Lisa Shea,

Daniel Edmonston,

Christopher L. Mosher,

Alexandre M. Shehata,

Zaza Cohen,

Valerie Allusson,

Gabriela BambrickSantoyo,

Noor ul aain Bhatti,

Bijal Mehta,

Aquino Williams,

Patricia Walters,

Ronaldo C. Go,

Keith M. Rose,

Rebecca Lisk,

Amy M. Zhou,

Ethan C. Kim,

Steven G. Coca,

Deena R. Altman,

Aparna Saha,

Howard Soh,

Huei Hsun Wen,

Sonali Bose,

Emily Leven,

Jing G. Wang,

Gohar Mosoyan,

Girish N. Nadkarni,

Pattharawin Pattharanitima,

Emily J. Gallagher,

John Guirguis,

Rajat Kapoor,

Christopher Meshberger,

Katherine J. Kelly,

Brian T. Garibaldi,

Celia P. CoronaVillalobos,

Yumeng Wen,

Steven Menez,

Rubab F. Malik,

Carmen Elena Cervantes,

Samir C. Gautam,

Jie Ouyang,

Sabu John,

Ernie Yap,

Yohannes Adama Melaku,

Ibrahim Mohamed,

Siddhartha Bajracharya,

Isha Puri,

Mariah Thaxton,

Jyotsna Bhattacharya,

John E. Wagner,

Leon Boudourakis,

H. Bryant Nguyen,

Afshin Ahoubim,

Kianoush Kashani,

Shahrzad Tehranian,

Leslie F. Thomas,

Dheeraj Reddy Sirganagari,

Pramod Guru,

Paul A. Bergl,

Jesús Rodríguez,

Jatan A. Shah,

Mrigank S. Gupta,

Princy Kumar,

Deepa G. Lazarous,

Seble Kassaye,

Tanya S. Johns,

Ryan Mocerino,

Kalyan Prudhvi,

Denzel Zhu,

Rebecca V. Levy,

Yorg Azzi,

Molly Fisher,

Milagros Yunes,

Kaltrina Sedaliu,

Ladan Golestaneh,

Maureen Brogan,

Neelja Kumar,

Michael Chang,

Jyotsana Thakkar,

Ritesh Raichoudhury,

Akshay Athreya,

Mohamed Farag,

Soo Jung Cho,

Maria Plataki,

Sergio Alvarez-Mulett,

Luis G. Gómez-Escobar,

Di Pan,

Stefi Lee,

Jamuna K. Krishnan,

William Whalen,

Ashley Macina,

Sobaata Chaudhry,

Benjamin G. Wu,

Frank Modersitzki,

Alexander S. Leidner,

Carlos Ruiz Martínez,

Jacqueline M. Kruser,

Richard G. Wunderink,

Alexander J. Hodakowski,

Eboni G. PriceHaywood,

Luis A. Matute-Trochez,

Anna E. Hasty,

Muner Mohamed,

Rupali S. Avasare,

David Zonies,

Meghan E. Sise,

Erik T. Newman,

Samah Abu Omar,

Shreyak Sharma,

Harkarandeep Singh,

Tanveer Shaukat,

Omer Kamal,

Heather Yang,

Meghan Lee,

Ian A. Strohbehn,

Jiahua Li,

Ariel Mueller,

Nicholas S. Cairl,

Gabriel Naimy,

Abeer Abu-Saif,

Danyell Hall,

Laura Bickley,

Chris Rowan,

Farah Madhani-Lovely,

Vasil Peev,

John J. Byun,

Andrew Vissing,

Esha M. Kapania,

Zoë Post,

Nilam Patel,

Joy-Marie Hermes,

Anne Sutherland,

Amee Patrawalla,

Barbara A. Danek,

Sowminya Arikapudi,

Jeffrey M. Paer,

Peter Cangialosi,

Mark Liotta,

Jag Sunderram,

Matthew T. Scharf,

Ayesha Ahmed,

Ilya Berim,

Jayanth S. Vatson,

Shuchi Anand,

Joseph E. Levitt,

Pablo García,

Suzanne M. Boyle,

Rui Song,

Ali Arif,

Sang Hoon Woo,

Xiaoying Deng,

Katharine Senter,

Moh’d A. Sharshir,

Vadym V. Rusnak,

Muhammad Ali,

Terri K. Peters,

Kathy Hughes,

Amber S. Podoll,

Michel Chonchol,

Sunita Sharma,

Ellen L. Burnham,

Arash Rashidi,

Rana Hejal,

Eric Judd,

Laura Latta,

Ashita J. Tolwani,

Timothy E. Albertson,

Jason Y. Adams,

Steven Y. Chang,

Rebecca M. Beutler,

Carl E. Schulze,

Etienne Macedo,

Harin Rhee,

Kathleen D. Liu,

Vasantha Jotwani,

Jay L. Koyner,

Chintan V. Shah,

Vishal Jaikaransingh,

Stephanie M. TothManikowski,

Min J. Joo,

James P. Lash,

Javier A. Neyra,

Nourhan Chaaban,

Madona Elias,

Yahya Ahmad,

Alfredo Iardino,

Elizabeth H. Au,

Jill H. Sharma,

Marie Anne Sosa,

Sabrina Taldone,

Gabriel Contreras,

David De La Zerda,

Alessia Fori,

Pennelope Blakely,

Hanna Berlin,

Tariq U. Azam,

Husam Shadid,

Michael Pan,

Patrick O’ Hayer,

Chelsea Meloche,

Rafey Feroze,

Kishan Padalia,

Abbas Bitar,

Jeff Leya,

Jennifer E. Flythe,

Matthew J. Tugman,

Emily Chang,

Brent R. Brown,

Ryan Spiardi,

Todd A. Miano,

Meaghan S. Roche,

Charles R. Vasquez,

Amar D. Bansal,

Natalie C. Ernecoff,

Sanjana Kapoor,

Siddharth Verma,

Huiwen Chen,

Csaba P. Kövesdy,

Miklos Z. Molnar,

Ambreen Azhar,

S. Susan Hedayati,

Mridula Nadamuni,

Shani Shastri,

DuWayne L. Willett,

Amanda D. Renaghan,

Kyle B. Enfield,

Pavan K. Bhatraju,

Adeel Malik,

Anitha Vijayan,

Christina Mariyam Joy,

Tingting Li,

Seth Goldberg,

Patricia F. Kao,

Greg Schumaker,

Nitender Goyal,

Caroline M. Hsu,

Asma Tariq,

Leah Meyer,

Ravi K. Kshirsagar,

Aju Jose,

Daniel E. Weiner,

Marta Christov,

Jennifer Griffiths,

Sanjeev Gupta,

Aromma Kapoor,

Perry Wilson,

Tanima Arora,

Ugochukwu Ugwuowo

Publication year - 2020

Publication title -

jama internal medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.14

H-Index - 342

eISSN - 2168-6114

pISSN - 2168-6106

DOI - 10.1001/jamainternmed.2020.6252

Subject(s) - tocilizumab , medicine , covid-19 , cytokine release syndrome , critically ill , interleukin 6 , critical illness , monoclonal antibody , severity of illness , cytokine , monoclonal , disease , immunology , antibody , virology , infectious disease (medical specialty) , outbreak

Therapies that improve survival in critically ill patients with coronavirus disease 2019 (COVID-19) are needed. Tocilizumab, a monoclonal antibody against the interleukin 6 receptor, may counteract the inflammatory cytokine release syndrome in patients with severe COVID-19 illness.

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