Association of Metformin Use With Risk of Lactic Acidosis Across the Range of Kidney Function | Zendy

Benjamin Lazarus | Zendy; Aozhou Wu | Zendy; JungIm Shin | Zendy; Yingying Sang | Zendy; G. Caleb Alexander | Zendy; Alex Secora | Zendy; Lesley A. Inker | Zendy; Josef Coresh | Zendy; Alex R. Chang | Zendy; Morgan E. Grams | Zendy

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Association of Metformin Use With Risk of Lactic Acidosis Across the Range of Kidney Function

Author(s) -

Benjamin Lazarus,

Aozhou Wu,

JungIm Shin,

Yingying Sang,

G. Caleb Alexander,

Alex Secora,

Lesley A. Inker,

Josef Coresh,

Alex R. Chang,

Morgan E. Grams

Publication year - 2018

Publication title -

jama internal medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.14

H-Index - 342

eISSN - 2168-6114

pISSN - 2168-6106

DOI - 10.1001/jamainternmed.2018.0292

Subject(s) - medicine , metformin , interquartile range , kidney disease , renal function , lactic acidosis , type 2 diabetes , diabetes mellitus , hazard ratio , retrospective cohort study , acidosis , cohort , intensive care medicine , endocrinology , insulin , confidence interval

Approximately 1 million patients in the United States with type 2 diabetes mellitus and mild-to-moderate kidney disease do not receive guideline-directed therapy with metformin. This may reflect uncertainty regarding the risk of acidosis in patients with chronic kidney disease.

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