Open AccessFailure of Investigational Drugs in Late-Stage Clinical Development and Publication of Trial Results
Author(s) -
Thomas J. Hwang,
Daniel Carpenter,
Julie C. Lauffenburger,
Bo Wang,
Jessica M. Franklin,
Aaron S. Kesselheim
Publication year - 2016
Publication title -
jama internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.14
H-Index - 342
eISSN - 2168-6114
pISSN - 2168-6106
DOI - 10.1001/jamainternmed.2016.6008
Subject(s) - medicine , clinical trial , investigational device exemption , investigational drugs , orphan drug , clinical research , food and drug administration , drug development , intensive care medicine , drug , pharmacology , bioinformatics , biology
Many investigational drugs fail in late-stage clinical development. A better understanding of why investigational drugs fail can inform clinical practice, regulatory decisions, and future research.
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