Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock | Zendy

Frank Bloos | Zendy; Evelyn Trips | Zendy; Axel Nierhaus | Zendy; Josef Briegel | Zendy; Daren K. Heyland | Zendy; Ulrich Jaschinski | Zendy; Onnen Moerer | Zendy; A. Weyland | Zendy; Gernot Marx | Zendy; Matthias Gründling | Zendy; Stefan Kluge | Zendy; Inès Kaufmann | Zendy; K. Ott | Zendy; Michael Quintel | Zendy; Florian Jelschen | Zendy; Patrick Meybohm | Zendy; Sibylle Rademacher | Zendy; Andreas MeierHellmann | Zendy; Stefan Utzolino | Zendy; Udo X. Kaisers | Zendy; Christian Putensen | Zendy; Gunnar Elke | Zendy; Maximilian Ragaller | Zendy; Herwig Gerlach | Zendy; Katrin Ludewig | Zendy; Michael Kiehntopf | Zendy; Holger Bogatsch | Zendy; Christoph Engel | Zendy; Frank M. Brunkhorst | Zendy; Markus Loeffler | Zendy; Konrad Reinhart | Zendy

Open Access

Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock

Author(s) -

Frank Bloos,

Evelyn Trips,

Axel Nierhaus,

Josef Briegel,

Daren K. Heyland,

Ulrich Jaschinski,

Onnen Moerer,

A. Weyland,

Gernot Marx,

Matthias Gründling,

Stefan Kluge,

Inès Kaufmann,

K. Ott,

Michael Quintel,

Florian Jelschen,

Patrick Meybohm,

Sibylle Rademacher,

Andreas MeierHellmann,

Stefan Utzolino,

Udo X. Kaisers,

Christian Putensen,

Gunnar Elke,

Maximilian Ragaller,

Herwig Gerlach,

Katrin Ludewig,

Michael Kiehntopf,

Holger Bogatsch,

Christoph Engel,

Frank M. Brunkhorst,

Markus Loeffler,

Konrad Reinhart

Publication year - 2016

Publication title -

jama internal medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.14

H-Index - 342

eISSN - 2168-6114

pISSN - 2168-6106

DOI - 10.1001/jamainternmed.2016.2514

Subject(s) - medicine , procalcitonin , septic shock , sepsis , selenium , intensive care medicine , shock (circulatory) , materials science , metallurgy

High-dose intravenous administration of sodium selenite has been proposed to improve outcome in sepsis by attenuating oxidative stress. Procalcitonin-guided antimicrobial therapy may hasten the diagnosis of sepsis, but effect on outcome is unclear.

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