Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families | Zendy

ChangFu Kuo | Zendy; Matthew J. Grainge | Zendy; Ana M. Valdes | Zendy; LaiChu See | Zendy; ShueFen Luo | Zendy; KuangHui Yu | Zendy; Weiya Zhang | Zendy; Michael Doherty | Zendy

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Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families

Author(s) -

ChangFu Kuo,

Matthew J. Grainge,

Ana M. Valdes,

LaiChu See,

ShueFen Luo,

KuangHui Yu,

Weiya Zhang,

Michael Doherty

Publication year - 2015

Publication title -

jama internal medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.14

H-Index - 342

eISSN - 2168-6114

pISSN - 2168-6106

DOI - 10.1001/jamainternmed.2015.3528

Subject(s) - medicine , family aggregation , heritability , twin study , relative risk , sibling , population , lupus erythematosus , systemic lupus erythematosus , immunology , disease , genetics , environmental health , antibody , confidence interval , psychology , developmental psychology , biology

Relatives of patients with systemic lupus erythematosus (SLE) appear to be at higher risk of SLE and other autoimmune diseases, but estimates of individual familial risks are largely unavailable or unreliable. Furthermore, relative contributions of genetic, shared, and unshared environmental factors to SLE susceptibility remain unclear.

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