Open AccessIntermittent vs Continuous Proton Pump Inhibitor Therapy for High-Risk Bleeding Ulcers
Author(s) -
Hamita Sachar,
Keta Vaidya,
Loren Laine
Publication year - 2014
Publication title -
jama internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.14
H-Index - 342
eISSN - 2168-6114
pISSN - 2168-6106
DOI - 10.1001/jamainternmed.2014.4056
Subject(s) - medicine , bolus (digestion) , proton pump inhibitor , continuous infusion , regimen , anesthesia , surgery
Current guidelines recommend an intravenous bolus dose of a proton pump inhibitor (PPI) followed by continuous PPI infusion after endoscopic therapy in patients with high-risk bleeding ulcers. Substitution of intermittent PPI therapy, if similarly effective as bolus plus continuous-infusion PPI therapy, would decrease the PPI dose, costs, and resource use.
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