The Challenge of Drug-Induced Aseptic Meningitis Revisited

Results | Four groups of drugs continue to be associated with DIAM (Table 1): nonsteroidal anti-inflammatory dr ugs (NSAID s), antibiotic s, immunosuppressiveimmunomodulatory (IS-IM), and antiepileptic drugs.1 Prior exposure to the associated drug was present in 26% to 35% of cases (Table 1). The interval between exposure and meningitis ranged from minutes to 5 months (Table 1). Most patients presented with headache, fever, meningismus, and mental status changes (Table 2). Underlying systemic disorders were often present, particularly systemic lupus ery-