Low-Dose Estradiol and the Serotonin-Norepinephrine Reuptake Inhibitor Venlafaxine for Vasomotor Symptoms | Zendy

Hadine Joffe | Zendy; Katherine A. Guthrie | Zendy; Andrea Z. LaCroix | Zendy; Susan D. Reed | Zendy; Kristine E. Ensrud | Zendy; JoAnn E. Manson | Zendy; Katherine M. Newton | Zendy; Ellen W. Freeman | Zendy; Garnet L. Anderson | Zendy; Joseph C. Larson | Zendy; Julie R. Hunt | Zendy; Jan L. Shifren | Zendy; Kathryn M. Rexrode | Zendy; Bette J. Caan | Zendy; Barbara Sternfeld | Zendy; Janet S. Carpenter | Zendy; Lee S. Cohen | Zendy

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Low-Dose Estradiol and the Serotonin-Norepinephrine Reuptake Inhibitor Venlafaxine for Vasomotor Symptoms

Author(s) -

Hadine Joffe,

Katherine A. Guthrie,

Andrea Z. LaCroix,

Susan D. Reed,

Kristine E. Ensrud,

JoAnn E. Manson,

Katherine M. Newton,

Ellen W. Freeman,

Garnet L. Anderson,

Joseph C. Larson,

Julie R. Hunt,

Jan L. Shifren,

Kathryn M. Rexrode,

Bette J. Caan,

Barbara Sternfeld,

Janet S. Carpenter,

Lee S. Cohen

Publication year - 2014

Publication title -

jama internal medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.14

H-Index - 342

eISSN - 2168-6114

pISSN - 2168-6106

DOI - 10.1001/jamainternmed.2014.1891

Subject(s) - venlafaxine , venlafaxine hydrochloride , medicine , tolerability , vasomotor , placebo , reuptake inhibitor , serotonin reuptake inhibitor , antidepressant , estrogen , menopause , sertraline , anesthesia , endocrinology , adverse effect , alternative medicine , pathology , hippocampus

Estrogen therapy is the gold standard treatment for hot flashes and night sweats, but some women are unable or unwilling to use it because of associated risks. The serotonin-norepinephrine reuptake inhibitor venlafaxine hydrochloride is used widely as a nonhormonal treatment. While the clinical impression is that serotonin-norepinephrine reuptake inhibitors are less effective than estrogen, these medications have not been simultaneously evaluated in one clinical trial to date.

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