Assessment of Hedgehog Signaling Pathway Activation for Craniofacial Bone Regeneration in a Critical-Sized Rat Mandibular Defect | Zendy

Matthew Q. Miller | Zendy; Logan F. McColl | Zendy; Michael R. Arul | Zendy; Jonathan Nip | Zendy; Vedavathi Madhu | Zendy; Gina Beck | Zendy; Kishan B. Mathur | Zendy; Vashaana Sahadeo | Zendy; Jason Kerrigan | Zendy; Stephen S. Park | Zendy; J. Jared Christophel | Zendy; Abhijit S. Dighe | Zendy; Sangamesh G. Kumbar | Zendy; Quanjun Cui | Zendy

Open Access

Assessment of Hedgehog Signaling Pathway Activation for Craniofacial Bone Regeneration in a Critical-Sized Rat Mandibular Defect

Author(s) -

Matthew Q. Miller,

Logan F. McColl,

Michael R. Arul,

Jonathan Nip,

Vedavathi Madhu,

Gina Beck,

Kishan B. Mathur,

Vashaana Sahadeo,

Jason Kerrigan,

Stephen S. Park,

J. Jared Christophel,

Abhijit S. Dighe,

Sangamesh G. Kumbar,

Quanjun Cui

Publication year - 2018

Publication title -

jama facial plastic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.815

H-Index - 59

eISSN - 2168-6092

pISSN - 2168-6076

DOI - 10.1001/jamafacial.2018.1508

Subject(s) - medicine , regeneration (biology) , craniofacial , bone morphogenetic protein 2 , bone morphogenetic protein , distraction osteogenesis , smoothened , anatomy , surgery , hedgehog signaling pathway , biology , microbiology and biotechnology , biochemistry , signal transduction , neuroscience , psychiatry , gene , distraction , in vitro

Osseous craniofacial defects are currently reconstructed with bone grafting, rigid fixation, free tissue transfer, and/or recombinant human bone morphogenetic protein 2. Although these treatment options often have good outcomes, they are associated with substantial morbidity, and many patients are not candidates for free tissue transfer.

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