Association of Serum Ustekinumab Levels With Clinical Response in Psoriasis
Author(s) -
Teresa Tsakok,
Nina Wilson,
Nick Dand,
Floris C. Loeff,
Karien Bloem,
David Baudry,
Michael Duckworth,
Shan Pan,
Angela Pushpa-Rajah,
Joseph F. Standing,
Annick de Vries,
Ali Alsharqi,
G Becher,
Ruth Murphy,
Shyamal Wahie,
Andrew Wright,
C.E.M. Griffiths,
Nick J. Reynolds,
Juliet N. Barker,
Richard B. Warren,
A. David Burden,
Theo Rispens,
Deborah Stocken,
Catherine Smith
Publication year - 2019
Publication title -
jama dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.128
H-Index - 166
eISSN - 2168-6084
pISSN - 2168-6068
DOI - 10.1001/jamadermatol.2019.1783
Subject(s) - medicine , ustekinumab , psoriasis , psoriasis area and severity index , observational study , dosing , clinical endpoint , prospective cohort study , clinical trial , immunology , disease , adalimumab
High-cost biologic therapies have transformed the management of immune-mediated inflammatory diseases. To optimize outcomes and reduce costs, dose adjustment informed by measurement of circulating drug levels has been shown to be effective in various settings. However, limited evidence exists for this approach with the interleukin 12 and interleukin 23 inhibitor ustekinumab.
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