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Efficacy and Safety of Guselkumab, an Anti–interleukin 23 Monoclonal Antibody, for Palmoplantar Pustulosis
Author(s) -
Tadashi Terui,
Satomi Kobayashi,
Yukari Okubo,
Masamoto Murakami,
Keiichiro Hirose,
Hiroshi Kubo
Publication year - 2018
Publication title -
jama dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.128
H-Index - 166
eISSN - 2168-6084
pISSN - 2168-6068
DOI - 10.1001/jamadermatol.2017.5937
Subject(s) - medicine , palmoplantar pustulosis , randomized controlled trial , dermatology life quality index , placebo , placebo controlled study , anakinra , gastroenterology , surgery , dermatology , psoriasis , double blind , pathology , disease , alternative medicine
Palmoplantar pustulosis (PPP) is a recalcitrant skin disease with no biologics currently approved for treatment. The involvement of interleukin 23 (IL-23) and cytokines of the type 17 helper T cell lineage in the pathogenesis of PPP has been recently postulated.

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