Molecular Profiling of Multiple Primary Merkel Cell Carcinoma to Distinguish Genetically Distinct Tumors From Clonally Related Metastases | Zendy

Kelly L. Harms | Zendy; Lorena Lazo de la Vega | Zendy; Daniel H. Hovelson | Zendy; Samantha Rahrig | Zendy; Andi K. Cani | Zendy; ChiaJen Liu | Zendy; Douglas R. Fullen | Zendy; Min Wang | Zendy; Aleodor A. Andea | Zendy; Christopher K. Bichakjian | Zendy; Timothy M. Johnson | Zendy; Scott A. Tomlins | Zendy; Paul W. Harms | Zendy

Open Access

Molecular Profiling of Multiple Primary Merkel Cell Carcinoma to Distinguish Genetically Distinct Tumors From Clonally Related Metastases

Author(s) -

Kelly L. Harms,

Lorena Lazo de la Vega,

Daniel H. Hovelson,

Samantha Rahrig,

Andi K. Cani,

ChiaJen Liu,

Douglas R. Fullen,

Min Wang,

Aleodor A. Andea,

Christopher K. Bichakjian,

Timothy M. Johnson,

Scott A. Tomlins,

Paul W. Harms

Publication year - 2017

Publication title -

jama dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.128

H-Index - 166

eISSN - 2168-6084

pISSN - 2168-6068

DOI - 10.1001/jamadermatol.2017.0507

Subject(s) - merkel cell carcinoma , merkel cell polyomavirus , copy number variation , medicine , primary tumor , merkel cell , metastasis , genetic heterogeneity , pathology , carcinoma , oncology , cancer research , biology , cancer , phenotype , gene , genetics , genome

Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma. In rare cases, the development of an additional cutaneous MCC tumor is clinically consistent with a second primary MCC tumor rather than a cutaneous metastasis, which has important treatment and prognostic implications.

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