Unilateral Axillary Toxic Erythema of Chemotherapy in a Patient With Previous Axillary Lymph Node Dissection

alprostadil. Alprostadil exerts a vasodilator, antiplatelet, and cytoprotective effect; it is an inhibitor of smooth muscle proliferation and fibrinolytic activity. Potential adverse events can occur, including fever, flushing, hypotension, hypocalcemia, and apnea. Prostanoids have also been used in patients with peripheral arterial disease (PAD) in association with revascularization to relieve pain or improve ulcer healing.5 Prostanoids are probably not as effective in treating PAD because this conditions it is not an alteration of microcirculation as in livedoid vasculitis and SS. In venous ulcers, PGE-1 has also been described to be effective.6 We describe the successful treatment of a case of SS with alprostadil. This drug induces immediate pain relief, complete healing, and prevention of new skin ulcers. Alprostadil may be a therapeutic alternative for other dermatological conditions secondary to obstructive vasculopathy of cutaneous microcirculation.