Eruptive Keratoacanthomas Associated With Leflunomide

Eruptive Keratoacanthomas Associated With Leflunomide The keratoacanthoma (KA) is a rapidly growing, welldifferentiated epidermal neoplasm that may be locally invasive or may spontaneously resolve. Most often, KA presents as a solitary lesion; however, multiple KAs can be seen in various syndromes, including Muir-Torre syndrome, the autosomal dominant Ferguson-Smith syndrome, and Grzybowskitype eruptive KAs.1 Several medications have been temporally associated with eruptive KAs. Recently in the literature there has been a report of eruptive KAs following treatment with leflunomide.2 The KAs resolved after stopping treatment with the medication. Herein, we report another case of multiple KAs in a patient undergoing treatment with leflunomide.