A Novel Chromosomal Translocation Associated WithCOL1A2-PDGFBGene Fusion in Dermatofibrosarcoma Protuberans | Zendy

Ikumi Nakamura | Zendy; Yoshiyuki Kariya | Zendy; Etsuko Okada | Zendy; Masahito Yasuda | Zendy; Shigetaka MATORI | Zendy; Osamu Ishikawa | Zendy; Hiroshi Uezato | Zendy; Kenzo Takahashi | Zendy

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A Novel Chromosomal Translocation Associated WithCOL1A2-PDGFBGene Fusion in Dermatofibrosarcoma Protuberans

Author(s) -

Ikumi Nakamura,

Yoshiyuki Kariya,

Etsuko Okada,

Masahito Yasuda,

Shigetaka MATORI,

Osamu Ishikawa,

Hiroshi Uezato,

Kenzo Takahashi

Publication year - 2015

Publication title -

jama dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.128

H-Index - 166

eISSN - 2168-6084

pISSN - 2168-6068

DOI - 10.1001/jamadermatol.2015.2389

Subject(s) - pdgfb , dermatofibrosarcoma protuberans , medicine , fusion gene , pathology , dermatofibrosarcoma , immunohistochemistry , cancer research , cd34 , gene , biology , platelet derived growth factor receptor , genetics , stem cell , receptor , growth factor

Dermatofibrosarcoma protuberans (DFSP) is a rare skin cancer that develops in the deep dermis to subcutaneous adipose tissues. A COL1A1-PDGFB gene fusion, leading to the constitutive expression of PDGFB, is the tumorigenic mechanism in most DFSP cases.

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