Dermal Damage Promoted by Repeated Low-Level UV-A1 Exposure Despite Tanning Response in Human Skin | Zendy

Frank Wang | Zendy; N. Smith | Zendy; Bao Anh Patrick Tran | Zendy; Sewon Kang | Zendy; John J. Voorhees | Zendy; Gary J. Fisher | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Dermal Damage Promoted by Repeated Low-Level UV-A1 Exposure Despite Tanning Response in Human Skin

Author(s) -

Frank Wang,

N. Smith,

Bao Anh Patrick Tran,

Sewon Kang,

John J. Voorhees,

Gary J. Fisher

Publication year - 2013

Publication title -

jama dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.128

H-Index - 166

eISSN - 2168-6084

pISSN - 2168-6068

DOI - 10.1001/jamadermatol.2013.8417

Subject(s) - irradiation , dermis , human skin , medicine , photoaging , matrix metalloproteinase , skin aging , melanin , epidermis (zoology) , skin cancer , dermatology , pathology , chemistry , anatomy , biochemistry , biology , cancer , physics , nuclear physics , genetics

Solar UV irradiation causes photoaging, characterized by fragmentation and reduced production of type I collagen fibrils that provide strength to skin. Exposure to UV-B irradiation (280-320 nm) causes these changes by inducing matrix metalloproteinase 1 and suppressing type I collagen synthesis. The role of UV-A irradiation (320-400 nm) in promoting similar molecular alterations is less clear yet important to consider because it is 10 to 100 times more abundant in natural sunlight than UV-B irradiation and penetrates deeper into the dermis than UV-B irradiation. Most (approximately 75%) of solar UV-A irradiation is composed of UV-A1 irradiation (340-400 nm), which is also the primary component of tanning beds.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research